Mapping of Genetic Determinants of Rubella Virus Associated with Growth in Joint Tissue

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Mapping of genetic determinants of rubella virus associated with growth in joint tissue.

Rubella virus (RV) strains vary in their abilities to replicate and persist in cell cultures derived from human joint tissue (synovial cells [SC]), and this arthrotropism appears to be linked to their association with joint symptoms in vivo. In order to map the genetic determinants of arthrotropism, an infectious clone of the Cendehill vaccine strain of RV was constructed, as well as two chimer...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2000

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.74.2.796-804.2000